Sildenafil Citrate for Women by Mohamed Nabih EL Gharib in Open Access Journal of Reproductive System and Sexual Disorders (OAJRSD) in Lupine Publishers
Sildenafil citrate (SC) is a medicinal drug used to treat male
erectile dysfunction and pulmonary hypertension. Sildenafil is a
selective and potent competitive inhibitor of the cyclic guanosine
monophosphate (cGMP) -specific phosphodiesterase-type 5
(PDE-5) enzymes, which, by preventing the breakdown of cGMP,
potentiate the action of NO in tissues that contain PDE-5. Thus,
increasing vasodilatation and potentiating the effects of nitrous
oxide (NO) on the vascular smooth muscle [1-2]. SC increases
uterine blood flow and potentiates estrogen-induced vasodilatation
[3].
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