Perimenopause and menopause per se significantly impacts on women
quality of life (QoL), especially due to vasomotor
symptoms (VMS); their duration is uncertain, and often long. Although
menopause hormone therapy (MHT) is the most effective
treatment for climacteric symptoms as a whole, its use is
contraindicated in some cases. Therefore, it is mandatory that different
treatment approaches be offered to women for whom hormone therapy is
contraindicated. As for treatment selection, there are a
wide range of nonhormonal options, both pharmacological and
nonpharmacological. These options include alternative or natural
therapies (isoflavones and Cimicifuga Racemosa), lifestyle modifications
and complementary therapies. Regarding pharmacological
strategies the literature review shows that serotonin-norepinephrine
reuptake inhibitors (SNRIs), selective serotonin reuptake
inhibitors (SSRIs), antihypertensives and anticonvulsants, decrease the
intensity and frequency of VMS, proving a clinically
significant improvement.
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