Klinefelter
syndrome patients are mostly clinically azoospermic, and before the era of
TESE, were unable to father genetically their own offspring. Nonmosaic
Klinefelter [NMK] patients have chances of fatherhood once sperm is harvested
from the epididymal seminiferous tubules and further injected in the ovarian
cytoplasm. We report a case of 36y old NMK patient, treated for 3 months with
supportive and hormonal medication achieving a pregnancy after TESE/ICSI. This
is the first published case of successful conception in a couple with a
nonmosaic Klinefelter father in Egypt using TESE/ICSI. Review of the literature
for any advantages of mTESE over TESE and conception demonstrated higher
pregnancy rates by TESE although the sperm retrieval rate was similar in both
techniques.
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