Lupine_Publishers The Study of Magnesium sulphate vs Diazepam in Eclampsia

Lupine Publishers-Open Access Journal of Reproductive System and Sexual Disorders.

 The Study of Magnesium sulphate vs Diazepam in Eclampsia by Tariq Masood Khan in Open Access Journal of Reproductive System and Sexual Disorders in Lupine Publishers.

Eclampsia is a life-threatening condition with highest mortality and morbidity characterized by uncontrolled hypertension unconsciousness fits albumin urea in the setting the of Pre-Eclampsia.

Study: An extensive elaborative study carried out from 2005 to 2009, to study the therapeutic and prophylactic role of Magnesium Sulphate and Diazepam in Eclampsia.

Study Period: Four years 2005 to 2009

Objective: To study MgSo4 Vs Diazepam reducing MMR, NMR in Eclampsia

Study Design: This was a comparative study. Total 500 patients of fulminent pre-Eclampsia/Eclampsia were studied included booked/un-booked patients attending Lady Willingdon Hospital were admitted evaluated assessed and put on MgSo4 Vs Diazepam divided in two groups. The results were compared which showed of MgSo4 as superior in efficacy of compared to Diazepam in improving overall mortality morbidity in Eclampsia.

Material and Methods: Total 500 patients of Eclampsia admitted and studied in Unit-2 Lady Willingdon Teaching Hospital of King Edward Medical University Lahore managed in ICU according to a special design proforma, protocol and were given MgSo4 and Diazepam for control of fits, Hydralazine, Labetalol and Isoket infusions for lowering-blood pressure (MgSO4) A+B. (Diazepam) with multi-disciplinary involvement divided in two groups compared and followed up.

Results: In Group-A there were 20 mothers and in Group-B 40 mothers died. It was observed that maternal mortality was significantly higher in Group-B women as compared to that of Group-A. i.e. (p-value=0.005) In Group-A there were 20 mothers and in Group-B 40 mothers died. It was observed that maternal mortality was significantly higher in Group-B women as compared to that of Group-A. i.e. (p-value=0.005).

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LupinePublishers Open Access Journal of Reproductive System

LupinePublishers_Open Access Journal of Reproductive System.

Advances in Adenomyosis Diagnosis Utilizing Transvaginal Ultrasonography-A Short Summary by
Kulvinder Kochar Kaur in Open Access Journal of Reproductive System and Sexual Disorders in Lupine_PUblishers.

Adenomyosis is a frequent condition, being present in 20% of general gynae population [1,2] and 30-40% of those attending assisted reproductive technology clinics, having a detrimental effect on cases of in vitro fertilization (IVF) [3,4]. Its main characteristics are presence of heterotopic endometrial glands and stroma within the myometrium, >2.5mm in depth of myometrium or more than one microscopic field at 10times magnification from the endometrium-myometrium junction, along with a variable degree of adjacent myometrial hyperplasia, causing globular and cystic enlargement of the myometrium, with some cysts filled with extravasated, hemolyzed red blood cells and siderophages [5]. Till now the main belief was that this could only get diagnosed with the use of histology only. As this disease gets commonly encountered in women over 40yrs, a belief got created that it was not a real disease. With the use of some imaging techniques like the magnetic resonance imaging and transvaginal ultrasound (TVS), it was found that adenomyosis had a typical appearance, which could be also detected in younger women, in the presence of symptoms or without, where it was found to have a typical appearance [6].
TVS is done in women of all ages and it showed typical sonographic findings, Different ultrasound imaging studies have been done to examine the diagnostic accuracy for finding adenomyosis as compared to that of histological examination of hysterectomy specimens. Also, the correlation of symptoms has been done. Biggest problem of using histology for adenomyosis diagnosis remains the big selection bias that has been observed. It had been seen that patients who had hysterectomy were usually in an advanced age and revealed heavy symptoms justifying surgery and thus do not represent the normal population. When a diagnosis of diffuse adenomyosis was done using TVS in younger fertile women who were with or without pain symptoms, a histological confirmation was found very occasionally of adenomyosis [7].
Inspite of this recently Tellum et al [8] tried to find the accuracy of TVS in diagnosis of adenomyosis. Using both 2D and 3D TVS, along with clinical symptoms, confirmed by histopathological examination they gave a predictive model, which showed a good test quality (area under curve [AUC]=0.86 [95% confidence interval=0.79-0.94], optimal cutoff 0.56, sensitivity of 85%, specificity78%). These 9 predictors were included ([sensitivity, specificity, β] or [AUCβ]; presence of myometrial cysts (51%,86%, β=0.86), fan shaped echo (36%, 92%, β=0.54), hyperechoic islets (51%, 78%, β=0.62), globular uterus (61%, 83%, β=0.2), normal uterine shape (83%, 61%, β=-0.75), thickest to thinnest ratio for uterine wall (0.61, β=0.26), maximum width of the junctional zone in sagittal plane (0.71, β=0.1), regular appearance of junctional zone (31%, 92%, β=-1.0) and grade of dysmenorrhea measured on a verbal numerical scaling (0.61, β=0.08). In view of various other studies, including that of Tellum et al. [8] showing a high accuracy of diagnosis, one can accept that one can make the diagnosis of adenomyosis just using ultrasonography (USG). One will be able to correlate the disease to real symptoms and fertility in the general population. Presence of one or more of USG features has often been observed in asymptomatic young ladies.

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Lupine Publishers: Journal of veterinary science - Lupine Publishers

Lupine Publishers: Journal of veterinary science - Lupine Publishers: New Tool Explains Live Mycobacteria Found in Retail Milk by Berwyn Clarke in CDVS in Lupine Publishers Most consumers of dairy ...

Flaky Academic Journals: Lupine Publishers "craves to select scientific con...

Flaky Academic Journals: Lupine Publishers "craves to select scientific con...: Lupine Publishers describes itself (on its website, 2/19/19) as a multidisciplinary, scholarly Open Access publisher focused on Genetic, ...

Open Access Journal of Reproductive System How to Determine the Ideal Increased Progesterone Levels Cutoff During Fresh In Vitro Fertilization Cycles: Is it Time to Move Forward-A Short Commentary

LupinePublishers_How to Determine the Ideal Increased ProgesteroneLevels Cutoff During Fresh In Vitro Fertilization Cycles:Is it Time to Move Forward-A Short Commentary by Kulvinder Kochar Kaur in Open Access Journal of Reproductive System and sexual disorders in Lupine_Publishers.

That increased progesterone(P) that is present on the day of human chorionic gonadotropin (HCG)trigger has an effect on the probable chances of a pregnancy resulting following a fresh embryo transfer has been a point that can be debated over the last 25 years [1-3]. A meta-analysis conducted by Venetis et al in 2013, confirmed the negative effect of progesterone on pregnancy following an ET [3]. They Further confirmed that by using proper analytical approaches one can find this correlation [4]. How this effect is brought about is by changing endometrial receptivity, an approach tested both by basic along with clinical research. Most importantly this support comes from cycles in which increased P do not affect if the embryos are frozen and transferred in subsequent cycle of frozen-thawed embryos [3]. Hence a proposal of freeze all/ freeze only policy was suggested as an answer to manage increased P found by the end of follicular phase.
However, the biggest problem that arises is what is the threshold of increased P that has to be considered as abnormal and thus needing any intervening procedure. With multiple thresholds getting in the literature more confusion has got created. Hence clinicians are still not sure that on measuring P on the day of HCG what is the exact threshold which they will employ to decide that they have to cancel a fresh ET and get into freeze-only policy ? This question has been taken up by Hill et al in 2018 [5] by an intense analysis of 7608 ART transfer cycles for getting different P thresholds and found it varied from 0.4 -3.0 ng/ml .Using different methods which kept in mind the sensitivity as well as specificity of every threshold they proposed ,in addition to the cost factor that would result if they used a freeze only(they preferred the term freeze only over freeze all a term adopted by the journal club Global [6]) policy what would the result be. They analyzed that if they used a threshold in between 1.5-2.0ng/ml, it would prove to be the most cost effective to use the freeze only approach [5]. Although they did find a statistically significant negative effect of P on pregnancy rates getting found if a threshold of 0.7ng/ml although they found if they used this low cut off the number required to treat markedly increased which decreased to 13 with the 1.5-2.0ng/ml cutoff.


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Lupine Publishers Forensic And Genetics Journal: Lupine Publishers: Processing and Analysis of Larg...

Lupine Publishers Forensic And Genetics Journal: Lupine Publishers: Processing and Analysis of Larg...: Lupine Publishers: Processing and Analysis of Large-Scale Seismic Sig... : Processing and Analysis of Large-Scale Seismic Signal in Hadoop P...

Lupine publishers publication ethics

Lupine Publishers Publication EthicsPublication Ethics: All the Journals in Lupine Publishers adheres to the highest possible ethical standards, for example, by the International Committee of Medical Journal Editors (ICMJE). If an ethical problem related to a submitted or published article is referred to the Editorial Board member, then he will evaluate the problem as outlined by appropriate bodies such as the ICMJE and the Committee on Publication Ethics (COPE), and take appropriate steps. The following are problems in the ethics of publication that every author should be familiar with. Violations of any of the following ethical principles may incur sanctions described below. Plagiarism All journals published by Lupine Publishers are committed to publishing only original material, i.e., material that has neither been published nor is under review elsewhere. Lupine Publisher’s journals as a participant of plagiarism pro software tool, to detect instances of overlapping and similar text in submitted manuscripts. Manuscripts that are found to have been plagiarized from a manuscript by other author(s), whether published or unpublished, will incur plagiarism sanctions. Duplicate Submission Manuscripts that are found to have been published elsewhere, or to be under review elsewhere, will incur duplicate submission/publication sanctions. If author(s) have used their own previously published work, or work that is currently under review, as the basis for a submitted manuscript, they are required to cite the previous work and indicate how their submitted manuscript offers novel contributions beyond those of the previous work. Citation Manipulation Submitted manuscripts that are found to include citations whose primary purpose is to increase the number of citations to a given author’s work, or to articles published in a particular journal, will incur citation manipulation sanctions.
Data Fabrication and Falsification Submitted manuscripts that are found to have either fabricated or falsified experimental results, including the manipulation of images, will incur data fabrication and falsification sanctions. Redundant Publications Redundant publications involve the inappropriate division of study outcomes into several articles. Publisher Responsibilities:  The publisher is committed to follow and comply with the International Committee of Medical Journal Editors (ICMJE) Recommendations.  The publisher does not influence the editors' decisions and pledges the review process probity.  The publisher is committed to respond to research misconduct complaints promptly, received atsupport@lupinepublishers.com. Use of Human and Animal Subjects: In any studies, involving human subjects must include a statement that their relevant institutional committee has approved the described work. In the case of experiments involving animals, the author(s) should provide a statement assuring that the described experiments have been approved by the relevant institutional committee. The following is a summary of our expectations from editors, reviewers, and author(s) to follow the publication ethics standards and the procedures of handling the unethical behaviors. 

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Lupine-Publishers Socio-Cultural Factors Affecting the Treatment of Breast Cancer Among Pakistani Women and Potential Strategies to Prevent Breast Cancer: A Narrative Review

Lupine-Publishers_Journal of Reproductive System and Sexual Disorders.

Socio-Cultural Factors Affecting the Treatment of Breast Cancer Among Pakistani Women and Potential Strategies to Prevent Breast Cancer: A Narrative Review by Sumera Aziz Ali in Journal of Reproductive System and Sexual Disorders in Lupine-Publishers.

The world health organization (WHO), since 1948, has defined health as “a state of complete physical, mental, and social wellbeing, not merely the absence of disease or infirmity”. This was later expanded to include intellectual, environmental, and spiritual health. This is a very remarkable statement, considering that it was originally created in 1948(WHO) [1].Personal responsibility is the driving force reflected in the above definition of health given by WHO, and the purpose defines destiny to achieve good health. If a state of ongoing health is our choice and purpose, then it is up to us to strive for this destiny ourselves. Life is a gift of God; the degree of health that we hold be a marker for how well we’ve taken care of this wonderful gift. Pakistan is ethnically, linguistically, religiously, and culturally a diverse society [2]. Our culture is a mixed culture. Pakistan is a Muslim country, although most people in Pakistan are Muslims, there is a strong influence of different cultures and their social activities on our culture, for example, Hindu culture influences are visible on our ceremonies and festivals. Despite significant progress has been made in recent years, the development indicators for Pakistan are still low. In addition, poverty is the major problem in our country, every person could not earn 1$ daily according to WHO.

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Lupine Publishers Journal of Otolaryngology: Lupine Publishers - Journal of Otolaryngology

Lupine Publishers Journal of Otolaryngology: Lupine Publishers - Journal of Otolaryngology: The Reasons Behind the Trending of Facial PlasticSurgery in Saudi Arabia by Almuhaya Reham in SJO - Lupinepublishers Background: No...

Lupine Publishers: Civil Engineering Research Journal-Lupine Publishe...

Lupine Publishers: Civil Engineering Research Journal-Lupine Publishe...: Failure Analysis of Thermo-Mechanically Treated (TMT) Bar During Bending Operation: A Metallurgical Investigation by Souvik Das in Trends...