Showing posts with label reproductive journals. Show all posts
Showing posts with label reproductive journals. Show all posts

Monday, June 24, 2019

Open Access Journal of Reproductive System How to Determine the Ideal Increased Progesterone Levels Cutoff During Fresh In Vitro Fertilization Cycles: Is it Time to Move Forward-A Short Commentary


That increased progesterone(P) that is present on the day of human chorionic gonadotropin (HCG)trigger has an effect on the probable chances of a pregnancy resulting following a fresh embryo transfer has been a point that can be debated over the last 25 years [1-3]. A meta-analysis conducted by Venetis et al in 2013, confirmed the negative effect of progesterone on pregnancy following an ET [3]. They Further confirmed that by using proper analytical approaches one can find this correlation [4]. How this effect is brought about is by changing endometrial receptivity, an approach tested both by basic along with clinical research. Most importantly this support comes from cycles in which increased P do not affect if the embryos are frozen and transferred in subsequent cycle of frozen-thawed embryos [3]. Hence a proposal of freeze all/ freeze only policy was suggested as an answer to manage increased P found by the end of follicular phase.
However, the biggest problem that arises is what is the threshold of increased P that has to be considered as abnormal and thus needing any intervening procedure. With multiple thresholds getting in the literature more confusion has got created. Hence clinicians are still not sure that on measuring P on the day of HCG what is the exact threshold which they will employ to decide that they have to cancel a fresh ET and get into freeze-only policy ? This question has been taken up by Hill et al in 2018 [5] by an intense analysis of 7608 ART transfer cycles for getting different P thresholds and found it varied from 0.4 -3.0 ng/ml .Using different methods which kept in mind the sensitivity as well as specificity of every threshold they proposed ,in addition to the cost factor that would result if they used a freeze only(they preferred the term freeze only over freeze all a term adopted by the journal club Global [6]) policy what would the result be. They analyzed that if they used a threshold in between 1.5-2.0ng/ml, it would prove to be the most cost effective to use the freeze only approach [5]. Although they did find a statistically significant negative effect of P on pregnancy rates getting found if a threshold of 0.7ng/ml although they found if they used this low cut off the number required to treat markedly increased which decreased to 13 with the 1.5-2.0ng/ml cutoff.


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https://lupinepublishers.com/reproductive-medicine-journal/abstracts/how-to-determine-the-ideal-increased-progesterone-levels-cutoff-during-fresh-in-vitro-fertilization.ID.000127.php 

  https://lupinepublishers.com/reproductive-medicine-journal/pdf/OAJRSD.MS.ID.000127.pdf

https://lupinepublishers.com/reproductive-medicine-journal/fulltext/how-to-determine-the-ideal-increased-progesterone-levels-cutoff-during-fresh-in-vitro-fertilization.ID.000127.php







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Monday, April 8, 2019

Lupine Publishers Reviews-Sildenafil Citrate for Women: (OAJRSD)



Sildenafil citrate (SC) is a medicinal drug used to treat male erectile dysfunction and pulmonary hypertension. Sildenafil is a selective and potent competitive inhibitor of the cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase-type 5 (PDE-5) enzymes, which, by preventing the breakdown of cGMP, potentiate the action of NO in tissues that contain PDE-5. Thus, increasing vasodilatation and potentiating the effects of nitrous oxide (NO) on the vascular smooth muscle [1-2]. SC increases uterine blood flow and potentiates estrogen-induced vasodilatation [3].

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Monday, March 11, 2019

Sexual Disorders Journals-Lupine Publishers- Case Presentation: Delayed Puberty: (OAJRSD)


Delayed puberty is extremely common condition in both boys and girls. Delayed puberty is defined clinically as the absence of the first signs of physical and hormonal signs of pubertal development beyond the normal range for the population. In the developed world, this means the absence of breast development by age 12 years in girls, or absence of testicular enlargement by age 14 years in boys. However, there are racial and ethnic variations in the timing of puberty, such as earlier onset of puberty in African American girls compared with Caucasian counterparts (Table 1). Puberty may be delayed for several years and still occurs normally, in which case it is considered constitutional delay, a variation of healthy physical development. Delay of puberty may also occur due to undernutrition, chronic illness or systemic disease, or to defects of the reproductive system (hypogonadism) or the body’s responsiveness to sex hormones. Any girl of 13 or boy of 14 years of age without signs of pubertal development falls more than 2.5 SD above the mean and is considered to have delayed puberty.

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Thursday, March 7, 2019

Open Access Journal of Reproductive System- Lupine Publishers- Infertility Caused by Jinn : (OAJRSD)







The World of Jinn is both sinister and intriguing. Their supernatural power (invisible in their natural state, shape-shifter, flying around the World in a second, illusion creation, possibility to possess the humans and create all kind of problems and even kill) can explain the mysteries, the diseases with unknown causes, unexplained Infertility. Knowing the traps of Shaytan (Satan or Devil or Evil Jinn) will help to diagnose properly and to remove the Evil of Shaytan. The Treatment of the Infertility (and of the diseases) caused by Black Magic or Jinn Possession or Evil Eye is only Ruqya, the specific verses of the Noble Quran, combined with the Negative Ions treatment for the quicker and better results.


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